Interaction of Dihydropyridine Calcium Channel Agonists and Antagonists with Adenosine Receptors
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چکیده
منابع مشابه
PHARMAC responds to Stewart Mann on dihydropyridine calcium channel antagonists.
PHARMAC’s legislative objective is “to secure for eligible people in need of pharmaceuticals, the best health outcomes that are reasonably achievable from pharmaceutical treatment and from within the amount of funding provided.” Two of the ways in which PHARMAC achieves this is by reference pricing and by negotiating sole supply contracts with pharmaceutical suppliers. When managed appropriatel...
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The blockade of L-type calcium channels by dihydropyridines, phenylalkylamines and benzothiazepines has been well described and forms the basis of a multibillion dollar market for the treatment of cardiovascular disease and migraine. More recently, neuron-specific calcium channels have become the subject of intense interest regarding their potential as therapeutic targets for the treatment of c...
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Intense efforts of many pharmaceutical companies and academicians in the A1 adenosine receptor (AR) field have led to the discovery of clinical candidates that are antagonists, agonists, and allosteric enhancers. The A1AR antagonists currently in clinical development are KW3902, BG9928, and SLV320. All three have high affinity for the human (h) A1AR subtype (hA1 Ki < 10 nM),> 200-fold selectivi...
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Introduction: There is currently a debate over the interaction between Ca2+ channels and cannabinoid system on learning and memory processing. In this study, we examined the effect of acute injection of cannabinoid agonist (Win- 55212-2) (Win) or antagonist (AM251), following chronic injection of verapamil, as a L-type Ca2+ channels blocker, on passive avoidance (PA) test in male Wistar rats...
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ژورنال
عنوان ژورنال: Pharmacology & Toxicology
سال: 1987
ISSN: 0901-9928,1600-0773
DOI: 10.1111/j.1600-0773.1987.tb01788.x